Prefillable polymer syringes have gained big interest by the pharmaceutical industry in recent years. Besides the traditional glass syringes, polymer syringes have established in the aesthetics as well as in the biotech and animal health sectors.
Many new, especially protein-based, biotechnologically manufactured medications, but also highly viscous or low-dosage drug formulations, and a series of oncologic and ophthalmologic medications make high demands of primary packaging. Gerresheimer Medical Systems offers a wide range of prefillable plastic syringes, especially for such applications. They are produced by COP (Cyclo Olefin Polymer) in an injection moulding process in accordance with cGMP.
There are quite some advantages of polymer syringes. For highly demanding drug formulations, especially the features “glue free” and “tungsten free” are important. Particulate matter caused by the siliconization of the syringes are often an issue for sensitive drug formulations. So low particle loads are achieved by a special siliconization and there are silicone free options feasible as well. Also, protein adsorption from the drug formulation on the container surface may pose a problem. As COP reacts different from glass, some test results on protein adsorption will be presented.
COP (Cyclo Olefin Polymer) syringes are distinguished by a high degree of break resistance, glass-like transparency and very low oxygen permeation compared to other plastics. They can be used directly for aseptic filling. COP releases no alkali ions, which means that the risk of a pH value shift is eliminated. Production with injection moulding process enables flexible designs – even customer-specific designs are possible. In comparison to glass more precise production tolerances are possible thanks to the exact injection moulding. This makes a higher degree of customized solutions possible, for example, when a lower remaining volume is required.
We also offer our customers an extensive portfolio of prefillable glass syringes that are adapted to the current requirements of the pharmaceutical industry and fulfil the requirements of modern filling systems.
The webinar will also introduce the new production facility for “Gx RTF® ClearJect®” COP syringes in Germany. We will give a deeper insight into the world of prefillable polymer syringes. The pros and cons of polymer syringes vs. glass syringes are discussed. You will have the opportunity to ask special questions to our technical expert. The webinar addresses packaging developers and pharmacists of all skill levels. Besides the material and syringe properties, also behaviour on filling lines and special requirements and adaptions in this field as well as drug-container interactions will be discussed.
In case prefillable polymer syringes are a topic in your company, don’t miss to register for this webinar.