Webinar:

Yield and productivity optimization for albumin and immunoglobulin crossflow operations

Sponsored by: Sartorius Stedim Biotech

Focused on:

  • Diafiltration
  • Plasma Purification
  • Immunoglobulin

Date: 29 January

193

Time: 3PM London/10AM New York

Improve the performance of crossflow operations of human plasma derived products

Concentration and diafiltration (buffer exchange) are commonly used methods in plasma purification. Crossflow operations (tangential flow filtration) for immunoglobulin and albumin require large installations for which the hardware (system), consumables (filter cassettes) and operational process parameters are critical to the overall performance of the unit operation.

Many of the challenges associated to those unit operations in commercial processes are related to the re-use of the filter cassettes which have a direct impact on key performance parameters such as product yield, the total process time of the unit operation (including cleaning and flushing steps) and the biosafety of the product. Those three parameters are determining the overall productivity of the unit operation and they have become incrementally important due to the growing market demand of PMDP’s (plasma derived medicinal products) with immunoglobulin as the main industry driver.

This webinar will discuss the system requirements for immunoglobulin and albumin within existing commercial processes regarding automation, process & product safety, piping diameters and system volume. Secondly the requirements for the filter cassettes is under focus and several aspects will be covered such as membrane choice, screen selection and the determination of the required membrane area.

Then an overview of the critical process parameters for immunoglobulin and albumin such as recirculation rate, inlet/outlet pressure, flux rates and other relevant parameters will be given. For each process parameter the typical operating ranges will be given which are considered to give a high-quality process.

In the last part of the webinar a few case studies are shown where the performance of PESU based membranes are compared against cellulose based membranes. The productivity of both membranes will be compared for immunoglobulin and albumin based on user data.

Please register now to reserve your spot for this exciting webinar and we look forward to welcoming you to our presentation.


Presented by

Peter Schmidt,

Application Specialist Manager Crossflow Technologies, Sartorius Stedim Biotech

Peter Schmidt joined Sartorius in 1994 and held various positions within the Sartorius Group. He started in research and development and worked in our engineering group as well as an application specialist.

Since 2012 he is leading the application specialists in the field of Purification technologies in Europe. They offer technical support related to topics like sterile filtration including pre-filtration steps, virus filtration and membrane chromatography. Peter offers 25 years experience on crossflow technologies. He works closely with most plasma manufacturers in Europe in terms of hardware and consumables.

Geert Lissens, PhD,

Head of Segment Marketing Blood and Plasma, Sartorius Stedim Biotech

Geert Lissens is leading the plasma market segment globally for Sartorius Stedim Biotech to address specific needs in this market and to evaluate potential new product developments on behalf of Sartorius in close collaboration with product management and product development. He also puts into action tactical initiatives that support the local technical and sales teams that cover the drug development and manufacturing sites of the end-users. Geert has 15 years of experience in the biotechnology industry and specializes in downstream processing and single use technologies. He held various positions at Sartorius as well as other suppliers to the biotech industry that include technical application specialist, sales, business development and marketing.


Key Learning Objectives

  • Challenges with crossflow operations in PMDP’s (plasma derived medicinal products)
  • Technical requirements for immunoglobulin and albumin concentration and diafiltration operations
  • Productivity determination of crossflow operations

Audience

  • Process Development Scientists
  • Process Development Managers
  • Process Engineers
  • Engineering Directors
  • Heads of research and development
  • Head of Manufacturing
  • Supervisor Manufacturing