Single-Use Downstream Bioprocess Intensification

Sponsored by: Sartorius Stedim Biotech

Focused on:

  • Membrane Chromatography
  • Biomanufacturing

Date: 11 December


Time: 3PM London/10AM New York

Membrane Chromatography in the Era of Single-Use and Continuous Manufacturing

Intensified and continuous biomanufacturing is a hot topic in the Biopharma industry as it increases productivity and efficiency. With the advent of robust and highly productive CHO cell lines and improved cell culture technology ever larger amounts of mAb and “mAb like” products are being produced which must be processed to high purity with increased efficiencies of time and cost. Sartorius Stedim Biotech is already offering unique technologies for single-use manufacturing, including new next generation process intensification tools for downstream processing (DSP) that have been or will be launched soon.

This webinar will provide an overview of Sartorius Stedim technologies for mAb DSP including soon to be launched process intensification tools. Following the product overview a case study for practical implementation of membrane chromatography in a clinical stage process will be presented by Dr. Greg Papastoitsis, VP of Development and Manufacturing at Compass Therapeutics.

Please register for our webinar to learn more about our platform solution and listen to a practical case study where these technologies have been brought to bear, experiences with new process technologies, and the use of novel Bioprocess Intensification Tools.

Presented by

Dr. Gregory Zarbis-Papastoitsis,

SVP of Process & Manufacturing

Dr. Greg Zarbis-Papastoitsis is the SVP of Process and Manufacturing at Compass Therapeutics. Compass engineers and manufactures antibody combinations utilizing a proprietary platform to treat cancer and other diseases. The company successfully filed its first IND in February 2019 for the treatment of solid tumors, and is currently in Phase 1 clinical studies. Dr. Zarbis-Papastoitsis has a broad industrial experience. As SVP of Process and Manufacturing Sciences at Eleven Biotherapeutics he and his group developed and transferred processes for manufacturing an IL-1 inhibitor, which was in Phase 3 clinical studies for Dry Eye Disease and Allergic Conjunctivitis, and an anti-IL6 antibody (successfully filed an IND), for treating Macular Edema. As Senior Director of Downstream and Analytical Development at PERCIVIA, LLC, he developed platform technologies for proteins produced with the PER.C6® human cell line. As Associate Director of Process and Analytical Development at Syntonix Pharmaceuticals he was responsible for the early clinical development of a long lasting Factor IX (ALPROLIX®). Before that he worked on the commercial process of HUMIRA® (Abbott | Abbvie), and the purification development of IL2-Diptheria Toxin, ONTAK® (Seragen). Dr. Zarbis-Papastoitsis received a Ph.D. in Biology at Binghamton University followed by 3 years of post doctoral studies at Boston University School of Medicine investigating proteases in Alzheimer disease.

Mr. Thomas Erdenberger,

Global Technology Consultant

Tom has worked in the biotechnology industry for more than 30 years both as an end-user as well as on the supplier side. He holds a degree in Applied Microbiology from Bowling Green State University and has an extensive background in industrial bioprocessing in process development and optimization, cGMP Manufacturing, tech transfer, facility start-up, and cross-functional project management, at companies such as Repligen, Genetics Institute, and Wyeth including start-up of Enbrel and Prevnar manufacture. Tom was an early adopter of single-use technology in the 1990’s and after long experience as an end user, transitioned to the supplier side at Xcellerex where he led the consumables engineering and manufacturing efforts. Tom joined Sartorius in 2016 as a Process Development Consultant and currently holds a position of Global Technology Consultant for Intensified and Continuous BioManufacturing

Key Learning Objectives

  • Learn more on Sartorius single-use bioprocessing tools
  • Find out which next generation process intensification tools are offered for downstream
  • See how Compass Therapeutics effectively integrated membrane chromatography technologies in a clinical stage process


  • Head of Manufacturing
  • Head of Research and Process Development
  • Project Managers
  • Process Development Scientists
  • Procurement
  • Manufacturing Engineers