Presented by Bristol Myers Squibb: Optimizing Upstream High-Throughput Biologics Development

Sponsored by: Roche CustomBiotech

Focused on:

  • Biologics Development

Date: 23 February


Time: 3PM London/10AM New York

The Importance of Metabolite Analyzers in Efficient High-Throughput Cell Culture Workflows

With timelines shortening and biologics pipelines growing, a need to generate robust process development methods quickly is essential. An Upstream High-Throughput Biologics Development (HTBD) strategy making use of a Tecan liquid-handling system with Design-of-Experiment (DOE) studies has been developed and implemented at the Devens site of Bristol Myers Squibb to meet this demand. However, we discovered that our previous metabolite analyzer greatly held back the potential of our high-throughput experiments, costing us what no-one can afford: time.

This presentation will be a discussion of the Upstream HTBD strategy at BMS - Devens, the success of this strategy, and how moving from a low-throughput to a high-throughput metabolite analyzer was instrumental for this success. This move effectively increased the number of unique experimental conditions evaluated in a two week period from 96 to 288.

A comparison between the previous and current analyzers will be made, depicting the importance of streamlining HT metabolite sampling workflows to prevent crashes, broken equipment, required replacements/calibrations, downtime, loss of data, and increase throughput. The improvements provided by our current analyzer to our workflow have made for a much more fluid high-throughput experience.

So, if you’re looking for a new approach to improve the efficiency of your DOE designs and high-throughput cell culture workflows, then please register.

Presented by

Erik Vandermark,


Graduated from Clarkson University in Potsdam, NY with a BS in Bio-Molecular Science in 2006 and a MS in Basic Science (Molecular Biology focus) in 2013.
In that same year, went to work for SUNY Upstate Medical University in Syracuse, NY doing pharmacology research.
Came to BMS in 2014 working in the Upstream High-Throughput group and has been at BMS ever since.

Key Learning Objectives

  • How to design large DOE upstream process development studies utilizing JMP and a liquid handler
  • How unoptimized workflows can negatively impact upstream HT DOE designs and throughput
  • How an efficient HT metabolite analyzer can streamline these workflows to significantly increase DOE design space and throughput


  • Biomanufacturing
  • Bioprocess Control
  • Bioprocess Analytics
  • Director
  • Manager
  • Technician
  • Scientist
  • Compliance
  • Engineering
  • Quality Assurance
  • Quality Control
  • Regulatory Affairs
  • Research and Development
  • Validation
  • Release Testing
  • Upstream Process Development
  • Upstream Process Manufacturing