Automated Purity and Integrity Check of Gene Therapy Vectors
Sponsored by: Vironova
- Gene Therapy Vectors
Date: 6 April
Time: 3PM London/10AM New York
Automated integrity analysis of AAV and Adenovirus particles using MiniTEMâ„¢
In this webinar a case study is presented how the integrity of Adeno-associated virus (AAV) and Adenovirus particles can be measured automatically. The analysis is performed using MiniTEM-enabled automatic imaging, detection, classification and quantification of particles. As a result of this analysis, a metric of the proportion of intact versus broken particles is presented.
MiniTEMâ„¢ is a compact low-voltage transmission electron microscope system designed for nanoparticle characterization that is easy to operate. The high-quality images it automatically acquires reveal particle morphologies that can be transformed into accurate metrics.
Learn more how MiniTEM offers objective and reliable visual and quantitative information on particle integrity, size and purity of virus and virus like structures.
Head of EM Services
Dr. Josefina Nilsson joined Vironova in 2007, at an early phase of the company. She has since then served to shape the company’s evolving services and solutions related to sub-visible particle characterization for the pharmaceutical industry.
Vironova is a Swedish company offering unique services for nanoparticle -characterization and viral clearance testing together with hardware and software solutions for advanced electron microscopy image analysis.
Manager Strategic Development, Vironova AB
One of the pioneers behind the Vironova software inventions for analyzing and quantifying viral structures in electron microscopy imagery. At Vironova Martin has been managing system development and techniques for data mining, machine learning and viral expression measurements.
Before joining Vironova Martin has also developed E-commerce models for Retail industry and control systems for industry automation. Martin has a solid foundation in applied mathematics from Royal Institute of Technology in Stockholm Sweden.
Key Learning Objectives
- How MiniTEMâ„¢ automatically images, detects and classifies viral particles in about one hour
- How to compare the proportion of intact versus broken Adeno-associated virus (AAV) in two samples
- How to compare the proportion of intact versus broken Adenovirus particles in two different samples
- Accuracy of a staining marker for on-grid particle integrity
- Analytics Scientists
- Senior Analytics Scientists
- Formulation Scientists
- Senior Formulation Scientists
- Biophysics Scientists
- Senior Biophysics Scientists
- Process Developers
- Process Development Scientists