Webinar: Accelerated High Throughput Process Development

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Date: 9th October

Days old: 4502

Time: 3PM London/10AM New York

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Development of an Automated Feedback Loop to Accelerate Reaction Screening

In a traditional high throughput experiment, the chemist will investigate many categorical variables (e.g., base, solvent, catalyst) while limiting continuous variables (e.g., time, temperature, stoichiometry) to a single or a few discrete values.

The presentation describes the development of an automated feedback loop for the Freeslate Core Module screening platform which allows for simultaneous screening of continuous variables. When running this logic loop, each reaction is sampled and then on the basis of this in-process analysis, the reaction can be moved to different temperature zones, have reagents added, or be left to continue under the initial conditions. By implementing the automated loop, data can be generated in a single screen that would typically require multiple rounds of screening. As currently implemented, the logic loop will support up to 48 experiments.

Be sure to register for this webinar presentation and learn how to accelerate process development in your organization.

Presented by

Kristin E. Price, Ph.D. ,

Principal Scientist, Pfizer

Kristin received her B.A. in Chemistry from Franklin and Marshall College in 2001. In June 2006, she completed her doctoral work at Cornell University under the guidance of Prof. D. Tyler McQuade. Since the summer of 2006, she has been working in Chemical Research and Development group at Pfizer, specializing in the development and application of new technology to process research.

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Key Learning Objectives

Understanding the capabilities and limitations of any automated system is crucial to the generation of reproducible data.
Inclusion of continuous variables in a screen will increase the number of potential hits.
By implementing a single feedback loop in a screen, it is possible to generate data that would require multiple rounds of more traditional screening.

Audience

Heads of Research and Development
Process Development Project Managers
Research Managers
Research Scientists
Research Department Directors