Trichoderma Produced Proteins: New Technologies and Foresights Beyond the Ordinary

Sponsored by: VTT

Focused on:

  • Enzymes

Date: 15 December


Time: 3PM London/10AM New York

How systems and synthetic biology can help to fill the food protein gap, create new materials and provide renewable energy

What are the most commonly used protein cell factories? Which fungus is the world champion of the protein production world? How to improve production strains for higher output and quality? What are the future trends and visions for protein cell factories?

Enzymes and recombinant proteins are commonly produced by cell factories for use as processing aids in food and feed, textile, and biofuel industries. Trichoderma reesei is very common fungus used for these purposes due to its high output yield and low production costs. New technologies such as CRISPR/Cas9 and synthetic promoters are making it possible to more quickly and more precisely engineer these systems for higher yields and larger profits. Furthermore, the use of Trichoderma could be expanded in the future to improve our health and expand our food supply.

This webinar reviews:

  • How systems biology can lead to strategies to achieve higher strain productivity
  • Engineering Trichoderma reesei strains using CRISPR/Cas9 and synthetic promoters to simplify strain construction and cultivation conditions
  • Future visions for Trichoderma protein production to go beyond the ordinary markets

Join this webinar to learn how you can harness the best new tools and strategies to take your production strains to the next level and improve cost effectiveness.

Presented by

Chris Landowski,

Research Team Leader

Christopher Landowski, Ph.D. (Pharmaceutical Sciences) is the Research Team Leader of the Protein Production Team at VTT. He has over 14 years of experience in recombinant protein production in bacteria, yeast, and filamentous fungi. His research work at VTT focuses on technologies to improve strain construction, boosting productivity, and reducing secreted protease activity. He is currently Principal Investigator on an Academy of Finland funded research project to study sugar sensing and enzyme secretion in filamentous fungi (2016-2020). Dr. Landowski has published 34 articles and is an inventor in 8 patents. Prior to VTT he was a researcher at the University of Michigan (USA) and Harvard Medical School (USA).

Markku Saloheimo,

Senior Principal Scientist

Dr. Markku Saloheimo is a Senior Principal Scientist working in the Protein production team of VTT. He has more than 20 years of experience in developing yeasts and filamentous fungi as protein production cell factories. He has worked extensively with the fungus Trichoderma reesei investigating e.g. gene regulation, protein secretion, production physiology and stress responses related to both recombinant protein and native enzyme production. He has lead a number of development projects where the productivity of proteins in this host system has been enhanced. He is an author of over 100 articles and inventor in 23 patent families.

Key Learning Objectives

  • Learn about filamentous fungi and other protein production cell factories
  • Learn in detail about the Trichoderma reesei protein expression system
  • How to improve production strains: higher productivity, reduced protease activity, synthetic promoters, CRISPR/Cas9 genome editing
  • Future of Trichoderma produced proteins: food ingredients, car parts, biopharmaceuticals


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